Plerixafor use in patients with previous mobilization failure: A multicenter experience

Tekgündüz E., Altuntaş F., Şivgin S., Aki Ş. Z., Dönmez A., Topçuoĝlu P., ...Daha Fazla

Transfusion and Apheresis Science, cilt.47, sa.1, ss.77-80, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.transci.2012.05.004
  • Dergi Adı: Transfusion and Apheresis Science
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.77-80
  • Anahtar Kelimeler: Chemotherapy, Mobilization failure, Plerixafor, Stem cell mobilization
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Plerixafor in conjunction with G-CSF (G-P) is an effective strategy for hematopoietic stem cell mobilization in patients with previously failed mobilization attempt. Here we report our results with G-P among patients with at least one mobilization failure with G-CSF alone (G) or G-CSF plus chemotherapy (G-C). The study included 20 consecutive patients with lymphoma and myeloma from five centers. In 14 (70%) patients, a minimum of 2×10 6/kg CD34+ stem cells were collected and 16 out of 20 patients (80%) were able to proceed to ASCT. Our study indicates that plerixafor can safely rescue patients with a history of mobilization failure. © 2012 Elsevier Ltd.