Preparation and characterization of poly (D,L-lactide-co-glycolide) microspheres for controlled release of poly(L-lysine) complexed plasmid DNA

ÇAPAN, YILMAZ; Woo, BH; Gebrekidan, S; Ahmed, S; DeLuca, PP

doi:10.1023/a:1018862827426

Preparation and characterization of poly (D,L-lactide-co-glycolide) microspheres for controlled release of poly(L-lysine) complexed plasmid DNA

ÇAPAN Y., Woo B., Gebrekidan S., Ahmed S., DeLuca P.

PHARMACEUTICAL RESEARCH, cilt.16, sa.4, ss.509-513, 1999 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 16 Sayı: 4
Basım Tarihi: 1999
Doi Numarası: 10.1023/a:1018862827426
Dergi Adı: PHARMACEUTICAL RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.509-513
Anahtar Kelimeler: controlled release, microspheres, DNA, DNA/poly(L-lysine) complex, poly(lactide-co-glycolide), GENE DELIVERY, THERAPY, SYSTEM
Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Purpose. To produce and characterize controlled release formulations of plasmid DNA (pDNA) loaded in poly (D,L-lactide-co-glycolide) (PLGA) microspheres both in free form and as a complex with poly (L-lysine).