Preparation and characterization of poly (D,L-lactide-co-glycolide) microspheres for controlled release of poly(L-lysine) complexed plasmid DNA

ÇAPAN, YILMAZ; Woo, BH; Gebrekidan, S; Ahmed, S; DeLuca, PP

doi:10.1023/a:1018862827426

Preparation and characterization of poly (D,L-lactide-co-glycolide) microspheres for controlled release of poly(L-lysine) complexed plasmid DNA

ÇAPAN Y. , Woo B., Gebrekidan S., Ahmed S., DeLuca P.

PHARMACEUTICAL RESEARCH, vol.16, no.4, pp.509-513, 1999 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 16 Issue: 4
Publication Date: 1999
Doi Number: 10.1023/a:1018862827426
Title of Journal : PHARMACEUTICAL RESEARCH
Page Numbers: pp.509-513
Keywords: controlled release, microspheres, DNA, DNA/poly(L-lysine) complex, poly(lactide-co-glycolide), GENE DELIVERY, THERAPY, SYSTEM

Abstract

Purpose. To produce and characterize controlled release formulations of plasmid DNA (pDNA) loaded in poly (D,L-lactide-co-glycolide) (PLGA) microspheres both in free form and as a complex with poly (L-lysine).