Research Information System
Saudi Medical Journal, vol.27, no.5, pp.642-645, 2006 (SCI-Expanded)
Objective: To evaluate the preemptive effects of diclofenac sodium, in combination with remifentanil and ketamine. Methods: A prospective, randomized, double blind, placebo-controlled trial was carried out at the Hacettepe University Hospital, Ankara, Turkey from September to December 2004. Forty-three, American Society of Anesthesiology physical status group I-II women, aged >18 years, who would undergo both diagnostic and operative laparoscopic surgery were randomly assigned into 2 groups. All patients received intraoperative 0.1 μgr.kg-1min-1 remifentanil infusion. Diclofenac (1 mg.kg-1 intramuscular) was administered, 20 minutes before the operation. Ketamine (0.8 mg.kg-1 intravenously) was administered 5 minutes before the skin incision and at completion of skin closure. We divided the patients into 2 groups; Group I (diclofenac + remifentanil + ketamine), Group II (remifentanil + ketamine). Pain was evaluated postoperatively using the visual analogue scale (VAS) while global satisfaction by verbal rating scale (VRS). Results: All 43 female patients have a mean ± SD age of 32.3 ± 6.5 years, height of 163 ± 5.3 cm, and weight of 62.9 ± 9.5 kg. The VAS and VRS scores and also time to first analgesic request were not different between the groups. In all groups, >98% of the patients were satisfied or very satisfied. Conclusion: We have not found any preemptive or additive effect of diclofenac sodium with the concomitant use of ketamine.