Aging and gender-related effects of tauroursodeoxycholic acid treatment on liver functions, plasma lipid profile, and oxidative stress

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Han S.

CUKUROVA MEDICAL JOURNAL, vol.47, no.1, pp.405-414, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.17826/cumj.1023909
  • Journal Name: CUKUROVA MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.405-414
  • Keywords: Aging, endoplasmic reticulum stress, oxidative stress, dyslipidemia, ENDOPLASMIC-RETICULUM STRESS, METABOLISM
  • Lokman Hekim University Affiliated: No

Abstract

Purpose: Aging is related to multiple and systemic dysfunctions in the body, accompanied by metabolic disorders and oxidative stress. Although studies are revealing the role of endoplasmic reticulum (ER) stress in aging-related pathologies, this relationship has not been fully elucidated. In this study, it was aimed to reveal changes in liver function, plasma lipids, and oxidative stress markers due to aging and gender, and to investigate how these parameters change with ER stress inhibitor tauro-ursodeoxycholic acid (TUDCA) treatment.