Ultrastructural and morphological analyses of the in vitro and in vivo hemostatic effects of Ankaferd blood stopper


Haznedaroglu B. Z. , HAZNEDAROĞLU İ. C. , Walker S. L. , Bilgili H., GÖKER H., KOŞAR A. , ...More

Clinical and Applied Thrombosis/Hemostasis, vol.16, no.4, pp.446-453, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.1177/1076029609343706
  • Title of Journal : Clinical and Applied Thrombosis/Hemostasis
  • Page Numbers: pp.446-453
  • Keywords: Ankaferd Blood Stopper, hemostasis, bleeding diathesis, liver, scanning electron microscopy, LIVER-DISEASE, COAGULATION, THROMBOSIS

Abstract

Ultrastructural and morphological analyses of a novel hemostatic agent, Ankaferd Blood Stopper (ABS), in comparison to its in vitro and in vivo hemostatic effects were investigated. High-resolution scanning electron microscopy (SEM) images accompanied with morphological analysis after topical application of ABS revealed a very rapid (<1 second) protein network formation within concurrent vital erythroid aggregation covering the classical coagulation cascade. Histopathological examination revealed similar in vivo ABSinduced hemostatic network at the porcine hepatic tissue injury model. Instantaneous control of bleeding was achieved in human surgery-induced dental tissue injury associated with primary and secondary hemostatic abnormalities. Ankaferd Blood Stopper could hold a great premise for clinical management of surgery bleedings as well as immediate cessation of bleeding on external injuries based on upcoming clinical trials. © 2010 The Author(s).