Color Doppler imaging of ocular hemodynamic changes in patients with rheumatoid arthritis unrelated to disease activity

ÜNAL Ö., Can M. E., Ozcan A., Ozcan M. E., ERTEN Ş., ÇAĞIL N.

Rheumatology International, vol.39, pp.1001-1006, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39
  • Publication Date: 2019
  • Doi Number: 10.1007/s00296-019-04275-y
  • Journal Name: Rheumatology International
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1001-1006
  • Keywords: Blood flow rate, Doppler ultrasonography, Rheumatoid arthritis, Vascular structures, ENDOTHELIAL DYSFUNCTION, ADHESION MOLECULE-1, E-SELECTIN, RISK, ATHEROSCLEROSIS, MANIFESTATIONS, VASCULITIS, BIOMARKERS, ICAM-1, EYE
  • Lokman Hekim University Affiliated: No


© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.We aimed to investigate how orbital blood flow rates in patients with rheumatoid arthritis (RA) are affected by the active and remission phase of the disease. This prospective study included a total of 56 patients with RA (study group) and 24 control individuals (control group). All RA patients were divided into two groups, as active (Group 1) and remission (Group 2) according to the disease activity index (DAS 28) score. For each eye, retrobulbar vascular structures were evaluated [central retinal artery (CRA), posterior ciliary artery (PCA), and ophthalmic artery (OA)], respectively. The peak systolic velocity (PSV) and end-diastolic velocity (EDV) values were obtained for each artery and the vascular resistance index (RI) measurement was calculated. The median RI of the OA was 0.70 (0.57; 0.79) in the control group, 0.77 (0.55; 0.87) in group 1, and 0.73 (0.47; 0.87) in group 2. The median RI in the PCA was 0.70 (0.56; 0.82) in the control group, 0.76 (0.52; 0.88) in the group 1, and 0.74 (0.52; 0.86) in the group 2. The median RI of CRA was 0.73 (0.48; 0.81) in the control group, 0.71 (0.64; 0.81) in group 1, and 0.68 (0.61; 0.85) in group 2. The RI value was a significant difference between control and group 1 (p < 0.05). Active and remission RA patients had different effects on the flow rate of eye blood vessels.