The effects of phototherapy on eosinophil and eosinophilic cationic protein in newborns with hyperbilirubinemia

Creative Commons License

Beken S., Aydın B., Zenciroǧǧlu A., Dilli D., Özkan E., Dursun A., ...More

Fetal and Pediatric Pathology, vol.33, no.3, pp.151-156, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.3109/15513815.2014.883456
  • Journal Name: Fetal and Pediatric Pathology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.151-156
  • Keywords: newborn, jaundice, phototheraphy, eosinophil, eosinophilic cationic protein, AFFECTS CYTOKINE PRODUCTION, NEONATAL JAUNDICE, PRETERM INFANTS, RISK-FACTOR, ACTIVATION
  • Lokman Hekim University Affiliated: No


Newborns with jaundice requiring or not requiring phototherapy (PT) are at greater risk of developing asthma later in life. In this study, we investigated the effect of PT treatment on eosinophil and eosinophilic cationic protein (ECP) levels in newborns with severe hyperbilirubinemia. Thirty newborns diagnosed with severe hyperbilirubinemia and exposed to light-emitting diode (LED) PT were enrolled into the study. Total serum bilirubin (TSB) levels, complete blood count and serum ECP concentrations were measured before and after PT. TSB and hemoglobin (Hb) counts were lower after PT (p = 0.001). There was no difference between leukocyte, lymphocyte, neutrophil and platelet count before and after PT. Eosinophil levels were increased after PT, although not significantly. ECP levels were higher after PT (p = 0.006). It may be speculated that newborns treated with LED PT, increased ECP might play a role in developing allergic diseases later in life. Copyright © Informa Healthcare USA, Inc.