Osseous metaplasia and subsequent spontaneous pregnancy chance: A case report and review of the literature


Gynecologic and Obstetric Investigation, vol.80, no.4, pp.217-222, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 80 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1159/000439529
  • Journal Name: Gynecologic and Obstetric Investigation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.217-222
  • Keywords: Assisted reproductive technologies, Infertility, Osseous metaplasia, Spontaneous pregnancy
  • Lokman Hekim University Affiliated: No


Backgrounds: What is not clear as yet is not only the etiology, but also the management of osseous metaplasia. We describe an infertile patient with osseous metaplasia and subsequent pregnancy after treatment and review the literature from infertility perspective. Method: We presented a 30-year-old woman with 8 years of secondary infertility who conceived spontaneously after removal of osseous tissue by operative hysteroscopy (HS) following one failed in vitro fertilization cycle. The current literature regarding the osseous metaplasia and fertility potential after removal of osseous tissue was also systematically reviewed in which 21 reports (n = 64 women) were eligible. Results: The available data suggest that restoration of endometrial cavity with HS or curettage provides a spontaneous pregnancy rate of 54.2% within 12 months. Conclusion: According to the available data, irrespective from the duration of subfertility, spontaneous pregnancy should be expected for at least 1 year following the 'complete' restoration of endometrial cavity. In that context, further infertility treatments such as assisted reproduction cycles should be postponed, unless there is another reason for infertility.