The effects of acute normovolemic hemodilution with hes (130/0.4) on hemodynamic parameters in open cardiac surgery Açik kalp cerrahisinde hes (130/0.4) ile yapilan akut normovolemik hemodilüsyonun hemodinamik parametrelere etkisi

Tokur M. E., KILIÇASLAN B., Kanbak M., Çil H., Çelebioǧlu B., AYPAR Ü.

Anestezi Dergisi, vol.24, no.3, pp.174-181, 2016 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3
  • Publication Date: 2016
  • Journal Name: Anestezi Dergisi
  • Journal Indexes: Scopus
  • Page Numbers: pp.174-181
  • Keywords: Acute normovolemic hemodilution, Coronary artery surgery, Hemodynamic parameters
  • Lokman Hekim University Affiliated: Yes


Objective: Hypothermia during CABG surgery to reduce the effect of viscosity-enhancing method of ANH is effective in providing adequate tissue perfusion during bypass. The purpose of this study was performed to investigate the effects of ANH on the hemodynamic parameters using HES (130/0.4) in open heart surgery. Method: After receiving ethical approval and patient consent; 22 patients to be applied CABG were included. After induction of anesthesia, patients were divided into 2 groups: ANH (n=11) and control (n=11). In the ANH group; 500 mL blood was taken using internal juguler catheter and at the same time for providing normovolemia, 500 mL of HES (130/0.4) was given to the patients. ANH did not performed in the control group. After induction, before CPB, after CPB, after operation and postoperative 24th hour; hemodynamic parameters (HR, MAP, CVP, CO, PCWP, CI), laboratory parameters (hematocrite, lactate, hemoglobine) and renal function parameters (BUN, creatinin) were evaluated. Results: In the hemodynamic parameters, SAP was lower in the control group before the CPB and the post-operative period. DAP and MAP were lower in the post-operative period in the ANH group. SAP, DAP and MAP values had no difference between the two groups. CVP, CO, PCWP and CI values had no difference in each of groups and between in the two groups. Hb values, in each of groups, were lower in the CPB, post-operative and postoperative 24th hour period. There were no difference between Hb, Htc, lactate, BUN and creatinine values, when comparing between the two goups. Conclusion: On the patients open heart surgery performed using HES (130/0.4) for ANH, we observed no negative effect on hemodynamic parameters and renal functions. We think that the patients who are suitable for CABG, clinically and according to the Htc values, ANH performed using HES (130/0.4) is a safety process.