Synthesis of some novel oxime ether derivatives and their activity in the 'behavioral despair test'

Bozdaǧ O., Gümüşel B. , Demirdamar R., Büyükbingöl E., Rolland Y., Ertan R.

European Journal of Medicinal Chemistry, vol.33, no.2, pp.133-141, 1998 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 2
  • Publication Date: 1998
  • Doi Number: 10.1016/s0223-5234(98)80038-x
  • Title of Journal : European Journal of Medicinal Chemistry
  • Page Numbers: pp.133-141
  • Keywords: fluvoxamine, aminoethyloxime ether derivatives, structural analysis behaviora, behavioral despair test, FLUVOXAMINE, ANTIDEPRESSANTS, INHIBITORS


In this study, a new series of 2-aminoethyloxime ether derivatives of some aralkylketones was synthesized. Their structures have been elucidated by UV, IR, 1H-NMR, 13C-NMR, mass spectra and elementary analysis. These compounds were then screened for their inhibition of immobility as an indicator of possible antidepressant activities by using the 'behavioral despair test'. Results showed that all the new compounds decreased the immobility time, however, the inhibition observed with AO3, AO4 and HO1 was significantly higher compared to fluvoxamine (p < 0.01).