Investigation of the protective effects of acetyl l-carnitine on cisplatin-ınduced uterus toxicity

SEYHAN Ş., SARIBAŞ G. S., COŞKUN AKÇAY N., GÜRGEN S. G., AKYOL S. N., GÖKTAŞ G., ...Daha Fazla

GAZI MEDICAL JOURNAL, cilt.29, sa.4, ss.294-298, 2018 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.12996/gmj.2018.81
  • Dergi Adı: GAZI MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.294-298
  • Anahtar Kelimeler: Acetyl L-carnitine, Apoptosis, Caspases, Cisplatin, TUNEL, Uterus
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Objective: The aim of the study was to investigate the prophylactic effects of acetyl L-carnitine against to uterus induced by cisplatin. Methods: Twenty-four female Wistar albino rats were divided into four groups: group I (control) was administered with saline; group II was administered with acetyl L-carnitine; group III was administered with cisplatin; group IV was pretreated with acetyl L-carnitine before cisplatin intraperitoneal injection. After 72h of cisplatin injection uterine tissue was removed. Histological and immunohistochemical investigations were performed, respectively. Results: We found that the number of TUNEL and caspases positive cells were increased in the endometrial epithelium, subepithelial connective tissue, endometrial glands and stroma in group III compare to the other groups. Furthermore inflammation and edema were observed in uterus of rats in group III. Conclusion: We can concluded that pretreatment of acetyl L-carnitine administration has protective effect on histological alteration of uterus caused by cisplatin.