Radiolabeled Drug Encapsulated Liposomes for Imaging and Treatment of Osteomyelitis

Silindir Günay M., Taş A., Çalamak S., Nigiz Ş.

IAEA BULLETIN (INTERNATIONAL ATOMIC ENERGY AGENCY), cilt.55098805, ss.103-104, 2024 (Scopus)

  • Yayın Türü: Makale / Özet
  • Cilt numarası: 55098805
  • Basım Tarihi: 2024
  • Dergi Adı: IAEA BULLETIN (INTERNATIONAL ATOMIC ENERGY AGENCY)
  • Derginin Tarandığı İndeksler: Scopus, Compendex
  • Sayfa Sayıları: ss.103-104
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Background: Osteomyelitis is the swelling and inflammation of bone tissue caused by infection, traumatic injuries, surgical procedures, prostheses, etc. accompanied by bone destruction. It was aimed to formulate levofloxacin (LEV) encapsulated, nanosized, PEGylated, radiolabeled liposomes. Methodology: In this study, LEV encapsulated, PEGylated, nanosized formulations were prepared by film method (6) and size reduction was performed by extrusion method and following characterized (measurement of mean particle size and distribution, zeta potential, percentage of entrapment efficiency). In vitro drug release analyses and in vitro antimicrobial activity analysis studies were performed for both two different bacterial strains. Liposomes were labeled with Ga-68 by a chelator according to the method of Helbok et al. and labeling efficiency was calculated by detecting the radioactivity with a gamma counter.