Influence of total intravenous and inhalational anaesthesia on haemostasis during tympanoplasty

ÖZER E., Çeliker V., AYPAR Ü., Başgül E.

Acta Anaesthesiologica Scandinavica, vol.47, no.10, pp.1242-1247, 2003 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 10
  • Publication Date: 2003
  • Doi Number: 10.1046/j.1399-6576.2003.00234.x
  • Journal Name: Acta Anaesthesiologica Scandinavica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1242-1247
  • Keywords: Coagulation, Fibrinolysis, GFC, Inhalational anaesthesia, PFA 100™, TIVA
  • Lokman Hekim University Affiliated: Yes


Background: Surgical trauma leads to systemic changes in haemostasis. Haematological changes activated by surgery may become so prominent that changes caused by anaesthesia might be hidden or underestimated. Therefore, we have undertaken a prospective study to compare the behaviour of selected factors involved in the coagulation and fibrinolytic systems. Methods: Forty healthy adult patients scheduled for otological surgery were enrolled in the study. Upon receiving informed consent, they were randomly assigned to receive either inhalational (IA) or total intravenous anaesthesia (TIVA). Platelet function (PFA100™), disseminated intravascular coagulopathy (DIC) panel, and generalized d-dimer (GFC) were studied during certain periods of anaesthesia to identify the changes in haemostasis. Results: Statistically, no significant change in DIC parameters were encountered between the two groups. No statistical difference was found between the two groups in the measured coagulation parameters, but statistically GFC showed slight activation in the 1st hour of surgical intervention. Conclusion: Presuming a minimal traumatic effect of surgical procedure on the determined variables, we conclude that different anaesthetic techniques have a negligible effect on platelet activation and fibrinolysis. The clinical relevance of coagulation activation and fibrinolysis during different anaesthetic techniques remains to be investigated.