Early versus delayed laparoscopic cholecystectomy for acute cholecystitis: A prospective, randomized study

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ÖZKARDEŞ A. B. , Tokaç M., Dumlu E. G. , Bozkurt B., Çiftçi A. B. , Yetişir F., ...More

International Surgery, vol.99, no.1, pp.56-61, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 99 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.9738/intsurg-d-13-00068.1
  • Title of Journal : International Surgery
  • Page Numbers: pp.56-61
  • Keywords: Acute cholecystitis, Laparoscopic cholecystectomy, Outcome assessment, Cost and cost analysis, ACUTE GALLBLADDER-DISEASE, COST-UTILITY, METAANALYSIS, SURGERY, TRIALS


We aimed to compare the clinical outcome and cost of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Sixty patients with acute cholecystitis were randomized into early (within 24 hours of admission) or delayed (after 6-8 weeks of conservative treatment) laparoscopic cholecystectomy groups. There was no significant difference between study groups in terms of operation time and rates for conversion to open cholecystectomy. On the other hand, total hospital stay was longer (5.2 ± 1.40 versus 7.8 ± 1.65 days; P = 0.04) and total costs were higher (2500.97 ± 755.265 versus 3713.47 ± 517.331 Turkish Lira; P = 0.03) in the delayed laparoscopic cholecystectomy group. Intraoperative and postoperative complications were recorded in 8 patients in the early laparoscopic cholecystectomy group, whereas no complications occurred in the delayed laparoscopic cholecystectomy group (P=0.002). Despite intraoperative and postoperative complications being associated more with early laparoscopic cholecystectomy compared with delayed intervention, early laparoscopic cholecystectomy should be preferred for treatment of acute cholecystitis because of its advantages of shorter hospital stay and lower cost.