Matrix metalloproteinase-9 promoter gene polymorphism (-1562C>T) in nasal polyposis
American Journal of Rhinology and Allergy, cilt.23, sa.6, ss.568-570, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 6
- Basım Tarihi: 2009
- Doi Numarası: 10.2500/ajra.2009.23.3371
- Dergi Adı: American Journal of Rhinology and Allergy
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.568-570
- Anahtar Kelimeler: Chronic inflammation, Genotype, Matrix metalloproteinase-9, Nasal polyposis, Paranasal sinus, Polymorphism, Susceptibility
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
Background: Expression of matrix metalloproteinase (MMP)-9 increases in nasal polyp tissues. However, the impact of MMP-9 genotypes on the development of nasal polyposis (NP) is unknown. The aim of this study was to examine a potential association of MMP-9 promoter gene polymorphism with the development of NP. Methods: A prospective and case-control study was performed on 93 patients with NP and 115 controls without sinonasal disease. Genotypes of MMP-9 (-1562C>T) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction. Results: The frequency of -1562CT genotype of MMP-9 was significantly high in NP patients with aspirin-induced asthma (p = 0.014). Distribution of T allele was significantly high in NP patients with aspirin-induced asthma (p = 0.013). MMP-9 genotypes were not associated with gender or the presence of atopy. Conclusion: In this study, MMP-9 -1562CT genotype was associated with susceptibility to NP in aspirin-induced asthmatic patients. Because this report is a population-based study, further research should be performed on larger study subjects to reveal the precise role of MMP-9 promoter gene polymorphism in the development of NP. Copyright © 2009, OceanSide Publications, Inc., U.S.A.