Matrix metalloproteinase-9 promoter gene polymorphism (-1562C>T) in nasal polyposis

Erbek S. S., Yurtcu E., Erbek S., Sahin F. I.

American Journal of Rhinology and Allergy, vol.23, no.6, pp.568-570, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.2500/ajra.2009.23.3371
  • Journal Name: American Journal of Rhinology and Allergy
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.568-570
  • Keywords: Chronic inflammation, Genotype, Matrix metalloproteinase-9, Nasal polyposis, Paranasal sinus, Polymorphism, Susceptibility
  • Lokman Hekim University Affiliated: No

Abstract

Background: Expression of matrix metalloproteinase (MMP)-9 increases in nasal polyp tissues. However, the impact of MMP-9 genotypes on the development of nasal polyposis (NP) is unknown. The aim of this study was to examine a potential association of MMP-9 promoter gene polymorphism with the development of NP. Methods: A prospective and case-control study was performed on 93 patients with NP and 115 controls without sinonasal disease. Genotypes of MMP-9 (-1562C>T) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction. Results: The frequency of -1562CT genotype of MMP-9 was significantly high in NP patients with aspirin-induced asthma (p = 0.014). Distribution of T allele was significantly high in NP patients with aspirin-induced asthma (p = 0.013). MMP-9 genotypes were not associated with gender or the presence of atopy. Conclusion: In this study, MMP-9 -1562CT genotype was associated with susceptibility to NP in aspirin-induced asthmatic patients. Because this report is a population-based study, further research should be performed on larger study subjects to reveal the precise role of MMP-9 promoter gene polymorphism in the development of NP. Copyright © 2009, OceanSide Publications, Inc., U.S.A.