The effects of different types of anesthesia on fetal IL-6 levels and natural killer cell activity Farkli anestezi̇ yöntemleri̇ni̇n fetal IL-6 düzeyleri̇ ve natural killer (NK) hücre akti̇vi̇tesi̇ üzeri̇ne etki̇leri̇

KILIÇASLAN B., Coşkun F., Başgül E., AYPAR Ü.

Anestezi Dergisi, vol.20, no.3, pp.134-140, 2012 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 3
  • Publication Date: 2012
  • Journal Name: Anestezi Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.134-140
  • Keywords: Anesthesia, obstetric, Cortisol, Interleukin-6, NK cells
  • Lokman Hekim University Affiliated: Yes


Objective: That they have insufficient immunity, mothers' immune system have an modulator impact to fetus; obstetrics anesthesia methods used is important. We investigated that the difference between different types of anesthesia on fetal IL-6 levels and NK cell activity in this study. Method: Thirty patients undergoing elective caesarean section were assigned to two groups: In Spinal Anesthesia Group (n:15), anesthesia was performed with hyperbaric bupivacaine and fentanyl. In General Anesthesia Group (n:15), induction was performed with thiopenthal, succinylcholine and sevoflurane. After clamping the umbilical cord, fentanyl and vecuronium were administered. Maternal blood was collected for IL-6 levels at preoperative period and final closure of the skin incision. After neonatal delivery, cord blood was collected for NK cell activity, IL-6 and Cortisol levels. Results: The time interval from the beginning of anaesthesia to umblical cord clamping (AbzKkz) was longer in spinal anaesthesia group (p<0.05) and there was negative correlation between this time and fetal IL-6 levels (p<0.05). Pre- postoperative maternal and fetal IL-6 levels were not influenced by anesthesia techniques (p>0.05). Fetal cortisol levels were higher in general anesthesia group (p<0.05). There was no difference between pre-and postoperative maternal IL-6 levels within groups (p>0.05). NK cell activity was smilar in both groups (p>0.05). There was negative correlation between NK cell activity and fetal IL-6 levels in general anesthesia group (p<0.05). Conclusion: Longer AbzKkz and its negatively correlation with fetal IL-6 level in spinal anesthesia group and higher fetal cortisol level in general anesthesia group may be important for fetal defense to stress and infection.