Thrombopoietin, interleukin-6, and P-selectin at diagnosis and during post-steroid recovery period of patients with autoimmune thrombocytopenic purpura


HAZNEDAROĞLU İ. C. , BÜYÜKAŞIK Y., KOŞAR A. , Kirazli Ş., Dündar S.

Annals of Hematology, vol.77, no.4, pp.165-170, 1998 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 77 Issue: 4
  • Publication Date: 1998
  • Doi Number: 10.1007/s002770050435
  • Title of Journal : Annals of Hematology
  • Page Numbers: pp.165-170
  • Keywords: autoimmune thrombocytopenic purpura megakaryocytopoiesis, thrombopoietin, interleukin-6, P-selectin, HUMAN MEGAKARYOCYTES INVITRO, LEUKEMIA INHIBITORY FACTOR, COLONY-STIMULATING FACTOR, GRANULE MEMBRANE-PROTEIN, SERUM-FREE CULTURE, STEM-CELL FACTOR, C-KIT LIGAND, PLATELET PRODUCTION, RECOMBINANT INTERLEUKIN-6, APLASTIC-ANEMIA

Abstract

Plasma concentrations of the most potent megakaryocytopoietic cytokines, thrombopoietin (TPO) and interleukin-6 (IL-6), and the platelet activation marker P-selectin were evaluated in 24 patients with autoimmune thrombocytopenic purpura (ATP) who responded to conventional steroid treatment, at diagnosis and after steroid-induced recovery. Baseline TPO concentration (median [interquartile range] = 0 [17.52] pg/ml) was significantly decreased and IL-6 (38 [19.75] pg/ml) and P-selectin (485 [393.75] ng/ml) were significantly elevated compared with healthy subjects (100 [68] pg/ml, 8 [7] pg/ml and 166 [69] ng/ml, respectively). Following steroid treatment, all values approached normal, i.e., TPO (20 [18.75] pg/ml) was increased and IL-6 (19.5 [13] pg/ml) and P-selectin (248 [172.5] ng/ml) were decreased, significantly. The decrease of TPO in ATP is suggested to occur due to increased megakaryocyte mass and, consequently, TPO clearance. The non-lineage-specific cytokine IL-6 may be elevated to compensate for megakaryocytopoiesis/thrombopoiesis. The elevation of P-selectin may reflect compensatory platelet hyperactivation; however, this molecule also might be a marker of platelet destruction.