Application of the ratio spectra derivative spectrophotometry and Vierordt's method to quantitative analysis of paracetamol and metamizol in a pharmaceutical formulation
Scientia Pharmaceutica, vol.67, no.1, pp.57-68, 1999 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 67 Issue: 1
- Publication Date: 1999
- Journal Name: Scientia Pharmaceutica
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.57-68
- Keywords: Metamizol, Paracetamol, Pharmaceutical formulation, Ratio derivative spectrophotometry, Vierordt's method
- Lokman Hekim University Affiliated: No
Abstract
Two new spectrophotometric methods, ratio spectra derivative spectrophotometry and Vierordt's method for the determination of paracetamol and metamizol in a mixture were described. The first method is based on the use of first derivative of the ratio spectra of paracetamol and metamizol. Calibration graphs were linear in the range 8-40 μg/ml for paracetamol and 12-48 μg/ml for metamizol. The mean recovery of this method was 100.13 ± 0.25% and 100.09 ± 0.23% for paracetamol and metamizol, respectively. In the Vierordt's method, the amounts of paracetamol and metamizol were determined by using their zero-order spectra in 0.1N HCl. The mean recovery for paracetamol and metamizol in the method were 99.81 ± 0.43% and 99.51 ± 0.60%, respectively. Both methods were successfully applied to a pharmaceutical formulation for the determination of these drugs.