Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin

Kupeli E., Orhan İ., Toker G., Yesilada E.

Journal of Ethnopharmacology, cilt.107, sa.2, ss.169-174, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 107 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.jep.2006.02.021
  • Dergi Adı: Journal of Ethnopharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.169-174
  • Anahtar Kelimeler: anti-inflammatory activity, antinociceptive activity, 12-O-tetradecanoyl-13-acetate (TPA), Maclura pomifera, scandenone, auriculasin, prenylated isoflavone, OSAGE ORANGE, AGGLUTININ, JACALIN
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

The aqueous, ethanolic and chloroform extracts and two prenylated isoflavones: scandenone (I) and auriculasin (II), isolated from the fruits of Maclura pomifera (Rafin.) Schneider, were investigated for their in vivo anti-inflammatory and antinociceptive activity. For the anti-inflammatory activity, both carrageenan-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models and for the antinociceptive activity, p-benzoquinone-induced abdominal constriction test were used. Scandenone, the chloroform and the ethanolic extracts were shown to possess antinociceptive activity and anti-inflammatory activity on carrageenan-induced hind paw edema model at 100 mg/kg dose. The same compound and the extract were also found to be highly active in (TPA)-induced mouse ear edema model whereas auriculasin and the H2O extract showed to be inactive in all of the assays. © 2006 Elsevier Ireland Ltd. All rights reserved.