Impact of contrast enhanced MRI on lymphocyte DNA damage and serum visfatin level

Yildiz S., Cece H., Kaya I., Celik H., Taskin A., Aksoy N., ...More

Clinical Biochemistry, vol.44, no.12, pp.975-979, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 12
  • Publication Date: 2011
  • Doi Number: 10.1016/j.clinbiochem.2011.05.005
  • Journal Name: Clinical Biochemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.975-979
  • Keywords: Alkaline comet assay, Gadolinium based contrast agents, High sensitive C reactive protein, Lymphocyte DNA damage, Magnetic resonance imaging, Nephrogenic systemic fibrosis, Visfatin.
  • Lokman Hekim University Affiliated: No


Objectives: Nephrogenic systemic fibrosis is a novel clinical entity encountered in subjects undergoing contrast enhanced magnetic resonance imaging (MRI). The aim of the present study is to evaluate the impact of contrast enhanced MRI exposure on lymphocyte DNA damage and serum levels of visfatin. Design and methods: Twenty-eight subjects undergoing contrast enhanced hypophysial MRI with omniscan® were included in the study. Blood samples were drawn before MRI, after non-contrast MRI and after contrast enhanced MRI from each subject. Lymphocyte DNA damage was analyzed by the alkaline comet assay, whereas serum visfatin level was assessed with enzyme immuno assay. Results: Both lymphocyte DNA damage and serum visfatin levels were statistically significantly increased in samples withdrawn after contrast enhanced MRI compared to samples withdrawn after non-contrast enhanced MRI and baseline samples (ANOVA p<. 0.001, for both). Conclusions: Findings of the present study revealed that the contrast enhanced MRI is associated with increased lymphocyte DNA damage and increased serum visfatin level. © 2011 The Canadian Society of Clinical Chemists.