Chronic lymphocytic leukemia in a child: A challenging diagnosis in pediatric oncology practice


Demir H. A. , Bayhan T., ÜNER A., KURTULAN O., Karakuş E., Emir S., ...More

Pediatric Blood and Cancer, vol.61, no.5, pp.933-935, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.1002/pbc.24865
  • Title of Journal : Pediatric Blood and Cancer
  • Page Numbers: pp.933-935
  • Keywords: ARNT mutation, children, chronic immunodeficiency, lymphadenopathy, lymphocytic leukemia, lymphocytosis, NERVOUS-SYSTEM INVOLVEMENT, TEL-ARNT FUSION, TRANSLOCATION, LYMPHOMA, TENSION, DISEASE

Abstract

Chronic lymphocytic leukemia/lymphoma (CLL) is an extremely rare disease during childhood. We report a 16-year-old female who presented with lymphadenopathies and she was diagnosed as T cell lymphoblastic lymphoma. Her chemotherapy response was minimal and clinical findings were unusual. Therefore, her biopsy specimen was re-examined and diagnosis was changed to CLL. Chemotherapy protocol including fludarabine, cyclophosphamide, rituximab was administrated and good response was observed. In our patient deletion at 1q21.2 region that includes aryl hydrocarbon receptor nuclear translocator (ARNT) gene was detected via comparative genomic hybridization method. ARNT gene deletion may be a new mutation in chronic lymphocytic leukemia development. Pediatr Blood Cancer 2014;61:933-935. © 2013 Wiley Periodicals, Inc.