Examination of the histopathologic changes on vessel walls due to intraarterial morphine, fentanyl, midazolam and dexmedetomidine administration in rats Siçanlarda morfi̇n, fentani̇l, mi̇dazolam ve deksmedetomi̇di̇ni̇ni̇ntra-arteri̇yel uygulanmasi ̇ile damar duvarinda meydana gelen hi̇stopatoloji̇k Deǧi̇şi̇kl̇ikleṙin i̇ncelenmeṡi

Kaya H., ÇELEBİ N., CANBAY Ö., Dinleyen D., UZUN Ş., MÜFTÜOĞLU S. F., ...More

Anestezi Dergisi, vol.15, no.4, pp.214-222, 2007 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 4
  • Publication Date: 2007
  • Journal Name: Anestezi Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.214-222
  • Keywords: Dexmedetomidine, Electrone microscopy, Fentanyl, Intra-arterial injection, Midazolam, Morphine
  • Lokman Hekim University Affiliated: Yes


Objective: To ascertain the changes seen in vessel walls due to the intra-arterial morphine, fentanyl, dexmedetomidine and midazolam injections. Methods: 78 adult Wistar albino rats weighing approximately 250-300 grams were used. Six of the rats were controls. The other 72 were divided into four groups each containing 18 rats and each group was further divided into three subgroups of six animals each. In Group 1,100 μg kg-1 dexmedetomidine; in Group 2, 5 mg kg-1 morphine; in Group 3, 0.2 mg kg-1 fentanyl and in Group 4, 5 mg kg-1 midazolam were injected into the abdominal aorta from the distal area of the renal branch. A total of 18 specimens were taken from each group after 1, 5 and 30 minutes of injection. Histopathologic changes were examined with routine electron microscopy. Results: In the midazolam, fentanyl and dexmedetomidine groups, increased interstitial edema and neutrophile infiltration were found over time (p<0.05). However; there were no significant changes in the morphine group over time. A statistically important difference was found at the 1st, 5th and 30th minutes with respect to interstisial edema between the groups and at 30th minutes with respect to neutrphil infiltration. Conclusion: Dexmedetomidine, morphine, fentanyl and midazolam cause edema in the early period (1st minute), while infitration and histopathologic changes occur in 5th and 30th minutes.