Purpose: This study aimed to compare health-related quality of life (HRQoL) between children with cerebral palsy (CP) and neuromuscular diseases (NMD). Material and methods: A total of 61 children with CP and 50 children with NMD, ages ranged from 5-18 years participated in this study. Patients' and parents' characteristics were recorded. The HRQoL was assessed using the Child Health Questionnaire Parent Form 50 (CHQ-PF50). The children's functional level was assessed using Barthel Index. Results: There were statistically significant differences between the groups in the scores of the general health perceptions, parental impact-emotional and parental impact-time subscales of the CHQ-PF50 (p<0.05). Children with CP and with NMD showed different patterns of HRQoL in terms of some subscales of the CHQ-PF50 (p<0.05). General health perception and parental impact-emotional and parental impact-time scores of children with NMD were worse than those with CP. Conclusion: In the pediatric group, quality of life of the children and their families affected differently in children with CP and NMD. Specific characteristics of both diseases should be taken into consideration while planning treatment programs and during follow-ups.