Exposure to Perchlorate in Lactating Women and Its Associations With Newborn Thyroid Stimulating Hormone

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Uçal Y., Sahin O. N., Serdar M. A., Blount B., Kumru P., Muhcu M., ...More

FRONTIERS IN ENDOCRINOLOGY, vol.9, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2018
  • Doi Number: 10.3389/fendo.2018.00348
  • Journal Name: FRONTIERS IN ENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: NIS inhibitors, perchlorate, nitrate, thiocyanate, colostrum, newborn thyroid health, SODIUM-IODIDE SYMPORTER, BOSTON-AREA WOMEN, PREGNANT-WOMEN, DRINKING-WATER, BREAST-MILK, THIOCYANATE, NITRATE, CALIFORNIA, ORIGIN, NIS
  • Lokman Hekim University Affiliated: No

Abstract

Background: Perchlorate, thiocyanate, and nitrate can block iodide transport at the sodium iodide symporter (NIS) and this can subsequently lead to decreased thyroid hormone production and hypothyroidism. NIS inhibitor exposure has been shown to reduce iodide uptake and thyroid hormone levels; therefore we hypothesized that maternal NIS inhibitor exposure will influence both maternal and newborn thyroid function.