Older age and capacity of colony forming unit in autologous peripheral derived hematopoietic cells

Civriz Bozdag S., BAY M., Ayyildiz E., TOPÇUOĞLU P., İLHAN .

Transfusion and Apheresis Science, cilt.47, sa.1, ss.113-116, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.transci.2012.05.011
  • Dergi Adı: Transfusion and Apheresis Science
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.113-116
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Background: Aging decreases bone marrow cellularity and alters the frequencies of stem cells. Aged hematopoietic stem cells can differ from their younger counterparts in functional capacity. Study design and methods: We aimed to evaluate the relation between the age and the ability of colony forming capacity of peripheral blood-derived hematopoietic cell products collected for autologous stem cell transplantation (AHSCT). Results: Elderly patients could be mobilized with lower total collected CD34+ cells. Colony forming capacity did not differ between young and old patients. Conclusion: This results can be translated into clinic as higher numbers of AHSCT candidates over age 60. © 2012 Elsevier Ltd.