Integrated Endocrine–Endothelial Biomarker Alterations in Chronic Occupational Arsenic Exposure
Journal of Occupational and Environmental Medicine, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Publication Date: 2026
- Doi Number: 10.1097/jom.0000000000003809
- Journal Name: Journal of Occupational and Environmental Medicine
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, Environment Index, MEDLINE, Public Affairs Index, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Health Research Premium Collection (ProQuest), Sociology Source Ultimate (EBSCO)
- Keywords: Arsenic exposure, Asymmetric dimethylarginine, Biomonitoring, Endothelial dysfunction, Occupational exposure, Thyroid hormones
- Lokman Hekim University Affiliated: Yes
Abstract
Objective: – To evaluate the effects of chronic occupational arsenic exposure on thyroid homeostasis and endothelial dysfunction using an integrated biomarker approach. Methods: – This cross-sectional study included 85 arsenic-exposed male workers and 85 controls. Urinary arsenic was measured as an exposure biomarker. Thyroid hormones and endothelial biomarkers were analyzed. Correlation and multivariable regression analyses were performed. Results: – Exposed workers had lower triiodothyronine and thyroxine levels and higher thyroid-stimulating hormone levels (all P < 0.001). ADMA and SDMA concentrations were significantly elevated. Urinary arsenic correlated with endocrine and endothelial biomarkers and independently predicted ADMA (β = 0.009) and SDMA (β = 0.003) (both P < 0.001). Conclusions: – Chronic occupational arsenic exposure is associated with concurrent endocrine and endothelial alterations, supporting integrated biomarker-based surveillance in occupational health.