Synthesis and acetylcholinesterase/butyrylcholinesterase inhibitory activities of (substituted/nonsubstituted benzal)hydrazone derivatives of 3-(6-substituted-3(2h)-pyridazinon-2- yl)propionohydrazides

ÖZÇELİK A. B., Gókçe M., Orhan İ., ŞAHİN M. G.

Fabad Journal of Pharmaceutical Sciences, vol.35, no.3, pp.153-161, 2010 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 3
  • Publication Date: 2010
  • Journal Name: Fabad Journal of Pharmaceutical Sciences
  • Journal Indexes: Scopus
  • Page Numbers: pp.153-161
  • Lokman Hekim University Affiliated: No

Abstract

In this study thirteen new substituted/nonsubstituted benzalhydrazone V derivatives of 3-(6-substituted-3(2H)-pyridazinon- 2-yl)propionohydrazide derivatives IV were synthesized as acetylcholinesterase and butyrylcholinesterase inhibitors. The structures of compounds V were elucidated by IR, 1H-NMR and MASS spectra. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChe) inhibitory activity of V derivatives was measured using Ellman's method. Only (4-chlorophenylbenzal)hydrazone derivatives of 3-(6-(4-fluorophenyl)-3(2H)-pyridazinon-2-yl)propionohydrazide Vi showed an excellent inhibitory effect against AChE. In addition, Vi showed a significant inhibitory effect against BChE.