Chlorpyrifos increases the levels of hippocampal NMDA receptor subunits NR2A and NR2B in juvenile and adult rats


Gultekin F., Karakoyun I., Sutcu R., Savik E., Cesur G., ORHAN H., ...More

International Journal of Neuroscience, vol.117, no.1, pp.47-62, 2007 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 117 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1080/00207450500535719
  • Journal Name: International Journal of Neuroscience
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.47-62
  • Keywords: chlorpyrifos, learning, memory, NR2A, NR2B, rat, ERYTHROCYTES IN-VITRO, CHOLINERGIC NEUROCHEMISTRY, BEHAVIORAL ALTERATIONS, ANTIOXIDANT ENZYMES, LIPID-PEROXIDATION, WEANLING RATS, EXPOSURE, NEUROTOXICITY, CHOLINESTERASE, INHIBITION

Abstract

The present study investigated the effect of chlorpyrifos on NMDA receptor subunits NR2A and NR2B in juvenile and adult rats. Chlorpyrifos was administered with the dose of 40 and 70 mg/kg to juvenile and adult rats, respectively. Chlorpyrifos significantly inhibited the AChE activity in juvenile and adult rats (p <.05). NR2A and NR2B levels significantly increased in juvenile and adult rats by chlorpyrifos application (p <.05). Increased NR2A and NR2B levels may reflect increased glutaminergic activity, consequently neuronal damage. In the case of neuronal damage, learning and memory could be affected negatively even though NR2A and NR2B increased. Copyright © 2007 Informa Healthcare.