Chlorpyrifos increases the levels of hippocampal NMDA receptor subunits NR2A and NR2B in juvenile and adult rats

Gultekin F., Karakoyun I., Sutcu R., Savik E., Cesur G., ORHAN H., ...Daha Fazla

International Journal of Neuroscience, cilt.117, sa.1, ss.47-62, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 117 Sayı: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/00207450500535719
  • Dergi Adı: International Journal of Neuroscience
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.47-62
  • Anahtar Kelimeler: chlorpyrifos, learning, memory, NR2A, NR2B, rat, ERYTHROCYTES IN-VITRO, CHOLINERGIC NEUROCHEMISTRY, BEHAVIORAL ALTERATIONS, ANTIOXIDANT ENZYMES, LIPID-PEROXIDATION, WEANLING RATS, EXPOSURE, NEUROTOXICITY, CHOLINESTERASE, INHIBITION
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

The present study investigated the effect of chlorpyrifos on NMDA receptor subunits NR2A and NR2B in juvenile and adult rats. Chlorpyrifos was administered with the dose of 40 and 70 mg/kg to juvenile and adult rats, respectively. Chlorpyrifos significantly inhibited the AChE activity in juvenile and adult rats (p <.05). NR2A and NR2B levels significantly increased in juvenile and adult rats by chlorpyrifos application (p <.05). Increased NR2A and NR2B levels may reflect increased glutaminergic activity, consequently neuronal damage. In the case of neuronal damage, learning and memory could be affected negatively even though NR2A and NR2B increased. Copyright © 2007 Informa Healthcare.