General Pharmacology, vol.29, no.2, pp.261-264, 1997 (SCI-Expanded)
1. In this study, we investigated the effects of chronic Auro-detoxin treatment for 5 and 10 weeks on reactivity to vascular agonists in the mouse aorta. 2. The maximum contractile responses to and the -log EC50 values of phenylephrine (Phe) were not changed with Auro-detoxin treatment. 3. The maximum contractile responses to 5 hydroxytryptamine (5-HT) were not changed over 5 weeks but were significantly increased with Auro detoxin treatment during a 10-week period. The log EC50 values of 5-HT were found to be significantly decreased in both treatment groups. 4. The maximum relaxation responses to acetylcholine (ACh) were decreased in both treatment groups. The log EC50 values of ACh were not changed in 5 weeks but significantly decreased in 10 Reek-treated animals. 5. Neither the maximum relaxation responses nor the -log EC50 values of sodium nitroprusside (SNP) were changed with Auro detoxin treatment. 6. These results suggest that chronic gold treatment affects vascular responses in the mouse aorta.