Akademik Veri Yönetim Sistemi
Indian Journal of Orthopaedics, 2025 (SCI-Expanded)
Aims: To evaluate the prognostic role of serum albumin level in the radiological progression of gonarthrosis. Methods: Two hundered and fifty patients with gonarthrosis (Group1: early stage gonarthrosis, Group 2: late-stage gonarthrosis), and 125 patients as a control group (Group 3) were included in this retrospective cross-sectional study. Age, gender, the Kellgren-Lawrence (KL) stage, serum albumin level, C-reactive protein (CRP)/albumin, platelet/lymphocyte, neutrophil/lymphocyte, lymphocyte/monocyte, lymphocyte/CRP, The Aggregate Index of Systemic Inflammation, Systemic Inflammatory Response Index, Systemic Immune Inflammation Index, Prognostic Nutritional Index (PNI), Modified Systemic Inflammation Score (mSIS) were recorded. Results: Albumin and PNI were lower compared to the Group 3 in the Group 1 and Group 2, and compared to the Group 1 in the Group 2 (for all p ≤ 0.001). mSIS was higher in the Group 1 and Group 2 compared to the Group 3 (p < 0.001 for both), and in the Group 2 compared to the Group 1 (p = 0.01). CRP/albumin was higher in Group 2 compared to Group 1 (p = 0.004). KL stage was moderately negatively correlated with albumin (r = −0.45 p < 0,001) and PNI (r = −0.40 p < 0.001). Albumin and PNI values have diagnostic value in predicting early-stage (the cut-off value for albumin: 40.05 g/L, for PNI: 52.28) and late-stage (the cut-off value for albumin: 39.35 g/L, for PNI: 51.03) gonarthrosis in patients without gonarthrosis and late-stage gonarthrosis in patients with early-stage gonarthrosis (the cut-off value for albumin level: 38.55 g/L, for PNI: 49.73). Conclusions: Serum albumin level has a prognostic role in the radiological progression of gonarthrosis.