Plasma antioxidant enzyme levels in smoker and non-smoker pregnant women and their correlation with uterine arterial doppler parameters

Creative Commons License

ÖZGAN ÇELİKEL Ö., Noyan V., Caglayan O.

Biomedical Research (India), vol.29, no.20, pp.3697-3700, 2018 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 20
  • Publication Date: 2018
  • Doi Number: 10.4066/biomedicalresearch.29-18-1082
  • Journal Name: Biomedical Research (India)
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core
  • Page Numbers: pp.3697-3700
  • Keywords: Cigarette, Oxidative stress, Pregnancy, Uterine artery
  • Lokman Hekim University Affiliated: No


© 2018, Scientific Publishers of India. All rights reserved.Introduction: Cigarettes contain many free radicals and cause oxidative stress in the body. Its contents decrease blood fluidity and blood stream by affecting the vascular endothelium; further, they directly or indirectly impair placental perfusion. Material and method: Catalase (CAT), malondialdehyde (MDA) and total sulfhydryl (SH) levels were analysed in venous blood specimens obtained from 49 smoker and 35 non-smoker pregnant women (age, 18-35 y) who were in the second trimester. Uterine arterial Doppler ultrasonography was performed to evaluate uterine perfusion. Pulsatile index (PI), resistance index (RI) and systole/diastole ratio (S/D) was measured. The smoker group was further subdivided into two groups: 1. those who smoked for <5 y and 2. Those who smoked for >5 y. Obtained data were analysed using the SPSS 11 statistical programme. Results: No significant differences were observed between the smoker and non-smoker groups in terms of demographic parameters and right–left uterine arterial Doppler parameters. The mean S/D ratio was significantly higher in the smoker group (P=0.01). The mean PI, mean RI and plasma MDA, CAT and total SH levels were similar in both groups. Although not statistically significant, the mean PI, RI and S/D ratio values of the smoker pregnant women who smoked for ≥ 5 y was found to be higher than of those who smoked for <5 y. Conclusion: There is no correlation between plasma antioxidant enzyme levels and uterine artery Doppler parameters; however, the duration of smoking may affect uterine perfusion.