Non-acidic mediated friedel-craft reaction of thiophene using EtAlCl 2

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Ünver H., Biyikoglu M., BULUT A.

Asian Journal of Chemistry, vol.25, no.15, pp.8772-8774, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 15
  • Publication Date: 2013
  • Doi Number: 10.14233/ajchem.2013.15607
  • Journal Name: Asian Journal of Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.8772-8774
  • Keywords: Thiophene, Acylation, Alkyl Lewis acid, Electrophilic aromatic substitution, BRIDGED FERROCENES, ACYLATION, CATALYSTS, EFFICIENT
  • Lokman Hekim University Affiliated: Yes


Since alkyl Lewis acids are BrØnsted bases, they give a non-acidic reaction media. In this context, acylation of thiophene is investigatedin the presence of EtAlCl2 and non-acidic media. Besides 8 examples of thiophene, one example for pyrrole is synthesized in moderate tohigh yields (up to 99 %).