Synthesis and antimicrobial activity of novel benzoxazoles
Zeitschrift fur Naturforschung - Section C Journal of Biosciences, cilt.67 C, sa.9-10, ss.466-472, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 67 C Sayı: 9-10
- Basım Tarihi: 2012
- Doi Numarası: 10.1515/znc-2012-9-1004
- Dergi Adı: Zeitschrift fur Naturforschung - Section C Journal of Biosciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.466-472
- Anahtar Kelimeler: Antibacterial Activity, Antifungal Activity, Benzoxazoles
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
A series of 2-(p-substituted-benzyl)-5-[[4-(p-chloro/fluoro-phenyl)piperazin-1-yl]ace tamido]-benzoxazoles were synthesized in need of new compounds for the fight against microbial pathogens. Their structures were elucidated by spectral techniques. These new derivatives, along with previously synthesized 2-(p-substituted-benzyl)-5-substituted-benzoxazoles, were evaluated for their antibacterial and antifungal activities against standard strains and drugresistant isolates in comparison with ampicillin, gentamicin sulfate, ofloxacin, vancomycin, fluconazole, and amphotericin B trihydrate. The minimum inhibitory concentration (MIC) of each compound was determined by a two-fold serial dilution technique. The compounds were found to possess a broad spectrum of antimicrobial activities with MIC values of 32-256 μg/ml. Although standard drugs were more active against the pathogenes employed in this study, the activities of the new benzoxazoles and reference drugs against drug-resistant isolates of the microorganisms were largely similar. © 2012 Verlag der Zeitschrift für Naturforschung, Tübingen.