Chemical constituents from solenostemma argel and their cholinesterase inhibitory activity


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Demmak R. G., Bordage S., Bensegueni A., Boutaghane N., Hennebelle T., Mokrani E. H., ...Daha Fazla

Natural Product Sciences, cilt.25, sa.2, ss.115-121, 2019 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.20307/nps.2019.25.2.115
  • Dergi Adı: Natural Product Sciences
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.115-121
  • Anahtar Kelimeler: Alzheimer’s disease, Cholinesterase, Molecular docking, Solenostemma argel
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

© 2019, Korean Society of Pharmacognosy. All rights reserved.Alzheimer’s disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the cholinesterase inhibitory activity of Solenostemma argel aerial part. Eight compounds were isolated and identified by NMR: kaempferol-3-O-glucopyranoside (1), kaempferol (2), kaempferol-3-glu-copyranosyl(1→6)rhamnopyranose (3) p-hydroxybenzoic acid (4), dehydrovomifoliol (5), 14,15-dihydroxy-pregn-4-ene-3,20-dione (6), 14,15-dihydroxy-pregn-4-ene-3,20-dione-15β-D-glucopyranoside (7) and solargin I (8). Two of them (compounds 2 and 3) could inhibit over 50 % of butyrylcholinesterase activity at 100 µM. Compound (2) displayed the highest inhibitory effect against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with a slight selectivity towards the latter. Molecular docking studies supported the in vitro results and revealed that (2) had made several hydrogen and π-π stacking interactions which could explain the compound potency to inhibit AChE and BChE.