Evaluation of ventricular repolarization in pregnant women with intrahepatic cholestasis


KIRBAŞ Ö., Biberoglu E. H., Kirbas A., Daglar K., Kurmus O., Danisman N., ...More

International Journal of Cardiology, vol.189, no.1, pp.25-29, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 189 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1016/j.ijcard.2015.04.001
  • Journal Name: International Journal of Cardiology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.25-29
  • Keywords: Arrhythmia, Bile acid, Pregnancy, QT dispersion, Cholestasis, ACIDS INDUCE ARRHYTHMIAS, BILE-ACIDS, QT-INTERVAL, CHOLIC-ACID, HEART-RATE, IN-VITRO, DISPERSION, ABNORMALITIES, DISEASE, MARKER
  • Lokman Hekim University Affiliated: Yes

Abstract

© 2015 Elsevier Ireland Ltd. All rights reserved.Background: Bile acids can induce arrhythmia by altering cardiomyocyte contractility or electrical conduction. The aim of this study was to investigate, by means of QT dispersion parameter detected by simple standard electrocardiogram (ECG), ventricular repolarization changes inpregnant women with and without intrahepatic cholestasis of pregnancy (ICP). Methods: In this case-control study including 75 pregnant women with cholestasis and 35 healthy, uncomplicated pregnancy cases, electrocardiographic QT interval durations and QT dispersion (QT-disp) parameters, corrected for the patients' heart rate using the Hodges formula, were investigated. Results: Maximum corrected QTinterval values were significantly higher in the severe ICP group than in the control group (p < 0.001) and significantly higher in the severe ICP group than in the mild ICP group (p = 0.01). The values of the mild ICP and control groups were similar. Corrected QT-disp values were also significantly higher in both ICP groups than in the control group and significantly higher in the severe ICP group than in the mild ICP group. Conclusion: Cholestatic diseases predispose patients to cardiovascular complications. Our data clearly demonstrated that QT-disp values were significantly altered in pregnant women with cholestasis when compared to the normal ones. This simple ECG parameter can be used to screen high-risk women, in order to better target counseling regarding lifestyle modifications and to conduct closer follow up and management of women with a history of ICP.