Synthesis and cytotoxicity studies on new pyrazole-containing oxime ester derivatives
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, vol.18, no.6, pp.1315-1322, 2019 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 18 Issue: 6
- Publication Date: 2019
- Doi Number: 10.4314/tjpr.v18i6.24
- Journal Name: TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1315-1322
- Keywords: Cytotoxic activity, E/Z isomer, Neuroblastoma cell, Oxime ester, Pyrazole, ANTICANCER ACTIVITY, DRUG DISCOVERY, ANTICONVULSANT, SOLUBILITY, IMIDAZOLE, A549
- Lokman Hekim University Affiliated: No
Abstract
Purpose: To synthesize a series of new 1-(2-naphthyl)-2-(1H-pyrazol-1-yl)ethanone oxime ester derivatives (5-12) with potential anticancer properties, and to determine their cytotoxic effects in mouse fibroblast and human neuroblastoma cell lines.