Phytosomes-Unraveling the Unique Properties of Plant-Derived Nanotechnological Drug Delivery Systems: A Review


ŞENOL DENİZ F. S., TUĞCU DEMİRÖZ F. N., ULUTAŞ O. K., ERDOĞAN ORHAN .

Current Medicinal Chemistry, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Basım Tarihi: 2025
  • Doi Numarası: 10.2174/0109298673319759250116104648
  • Dergi Adı: Current Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Anahtar Kelimeler: bioavailability, drug delivery, natural products, Phytosomes, plant extracts, toxicity
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Phytosomes are innovative compounds that enhance the bioavailability of plant-derived compounds, making them more effective in pharmaceuticals and nutraceuticals. By improving cellular absorption, phytosomes allow lower doses of plant extracts to achieve therapeutic effects, which may reduce both cost and the risk of potential side effects. The incorporation of phospholipids in phytosomes not only stabilizes the active compounds but also protects them from degradation in the gastrointestinal tract, potentially increasing their shelf life and efficacy. Despite their promise, more clinical trials are essential to fully validate the safety and therapeutic benefits of phytosomes. Ongoing research and developments may lead to a better understanding of their mechanisms of action and safety profiles and broaden their application in medicine.