The role of 15-lipoxygenase-l expression and its potential role in the pathogenesis of endometrial hyperplasia and endometrial adenocarcinomas

Sak M., ALANBAY İ., Rodriguez A., Gokaslan T., Borahay M., Shureiqi I., ...More

European Journal of Gynaecological Oncology, vol.37, no.1, pp.36-40, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.12892/ejgo30i7.2016
  • Journal Name: European Journal of Gynaecological Oncology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.36-40
  • Keywords: 15-LOX-1, endometrial hyperplasia, Endometrial adenocarcinomas
  • Lokman Hekim University Affiliated: No


Purpose of Investigation: To investigate the presence of 15-lipoxygenase-1 (15-LOX-1) expression and its potential role in the pathogenesis of endometrial hyperplasia and endometrial adenocarcinomas. Materials and Methods: The authors investigated the presence of 15-LOX-l expression in samples from patients diagnosed with normal endometrium (n = 12), endometrial hyperplasia (n = 12), and endometrial cancer (n = 12). The immunohistochemical stainings were scored by three independent pathologists. A Western blot of 15-LOX-l determined the presence of protein expression in normal endometrium. A Kolmogorov-Smimov test was used to evaluate the data's distribution pattern. For pairwise comparisons of the combined scores between groups, the Mann-Whitney U test was used. Results: Based on the combined scores for 15-LOX-l expression, strong immunochemistry staining was observed in samples diagnosed with normal endometrium. There was a significant difference in 15-LOX-l expression between normal endometrium and endometrial adenocarcinoma (p = 0.03). Comparing tissues from normal endometrium and endometrial hyperplasia, there was a decline in the expression from normal endometrium to endometrial hyperplasia. However, the difference was not statistically significant. Conclusion: The present results show that a decrease of 15-LOX-l expression in the endometrial tumorigenesis process, starting from normal endometrium to hyperplasia and endometrial cancer, might be a trigger. Further studies are required to determine its potential use as a marker in a larger randomized multicenter study.