Pancreatic Tumour Microenvironment and Microenvironment Targeted Therapeutic Approaches

Kaçaroğlu D.

Acute and Chronic Pancreatitis, Luis Rodrigo, Editör, IntechOpen, London, ss.1-20, 2025

  • Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
  • Basım Tarihi: 2025
  • Yayınevi: IntechOpen
  • Basıldığı Şehir: London
  • Sayfa Sayıları: ss.1-20
  • Editörler: Luis Rodrigo, Editör
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Pancreatic cancer is characterised by high metastatic potential and poor survival rates. The major reason for this is the failure of the therapeutic agent to reach the target cells due to the dense desmoplastic microenvironment formed in pancreatic tumour. The formation of an immunosuppressive tumour microenvironment due to disruption of matrix morphology reduces the success rate of immunotherapy, chemotherapy and targeted therapy methods used in the treatment of Pancreatic Adenoductal Carcinoma (PDAC). In this chapter, the components of the pancreatic tumour microenvironment; cancer cells, stromal cells (mesenchymal stem cells, fibroblasts, pancreatic stellate cells, cancer-associated fibroblasts), immune system cells and extracellular components (ECM, cytokines, growth factors, DNA and small RNAs) are explained.  This stroma is a vital dynamic structure that regulates tumour growth, metabolism, vascularisation, drug resistance, immune tolerance and metastasis pathways. To comprehend and manage the intense desmoplastic stroma, it is crucial to elucidate the behaviour of the microenvironment components in pancreatic cancer. The microenvironment of PDAC, the most common type of pancreatic cancer, and microenvironment-targeted therapeutic approaches are then presented as in vitro, in vivo and clinical phase studies.