Copyright © 2016 by Türkiye Klinikleri.Colloid milium is a rare seen degenerative disease. Three different variant were described: adult, juvenile and nodular colloid degeneration. All of these variants have different ethiologic factors and also different clinical and histopatological appearances. Adult colloid milium has a dermal origin and chronic sun exposure is the most important ethiologic factor. Adult type is the most common above all variants. Mostly it effects middle aged and fair-skinned people. Males are effected four times more than females. Histopathologically, amorph eosinophilic materials expanding the papillary dermis and extending into the middle dermis. Solar elastosis is also present. Periodic Acid Schiff stains highlight the colloid material. Acral persistant pustular musinosis, nodular amyloidosis, syringoma, senile sebaceous hyperplasia must be thought as differential diagnoses. Histopathologically colloid milium is easily differentiated from all these. Though topical retinoids, dermaabrasion, diathermy, cryotherapy, Er-YAG laser are attempted for treating the disease, sun protection is the most recommended protective measure. In this report, unilaterally chronic sun exposed 53 years old taxi driver male with semilucent dome-shaped papules on his left ear helicis and left hand dorsum diagnosed clinically and histopathologically as colloid milium and treated with sunprotection agent and topical tretinoin was presented. The case was evaluated in the light of current literature.