Therapeutic Treatment with Abdominal Adipose Mesenchymal Cells Does Not Prevent Elastase-Induced Emphysema in Rats
TURKISH THORACIC JOURNAL, vol.21, no.1, pp.14-20, 2020 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 21 Issue: 1
- Publication Date: 2020
- Doi Number: 10.5152/turkthoracj.2019.180136
- Journal Name: TURKISH THORACIC JOURNAL
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.14-20
- Lokman Hekim University Affiliated: No
Abstract
OBJECTIVES: Emphysema and chronic bronchitis have different pathophysiologies but both are significant components of chronic obstructive lung disease (COPD). The levels of Matrix metalloproteinase (MMP)-9 in the bronchoalveloar lavage fluid (BALF) and in serum indicate the presence of emphysema. Intratracheal administration of elastase has been used to create a rat model of emphysema. Adipose tissue-derived mesenchymal stem cells (MSC) have been postulated to prevent or reverse emphysema, however, this has not been examined in the rat model of elastase-induced emphysema.