Predictive value of urinary neutrophil gelatinaseassociated lipocalin and serum ischemia-modified albumin for early diagnosis in patients with contrastinduced acute kidney injury İdrar nötrofil jelatinaz ilişkili lipokalin ve serum iskemi modifiye albümin düzeylerinin kontrastla ilişkili böbrek hasarının erken tanısında öngördürücü değeri


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Apaydın Z., Kılıç A., Ekici B., Erkan A. F. , Özdemir S., Oğuz A. K.

Haseki Tip Bulteni, vol.58, no.3, pp.234-239, 2020 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.4274/haseki.galenos.2020.5847
  • Journal Name: Haseki Tip Bulteni
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.234-239
  • Keywords: Neutrophil gelatinase-associated lipocalin, ischemia modified albumin, contrast-induced acute kidney injury, INDUCED NEPHROPATHY, BIOMARKER, NGAL
  • Lokman Hekim University Affiliated: Yes

Abstract

© 2020 by The Medical Bulletin of İstanbul Haseki Training and Research Hospital The Medical Bulletin of Haseki published by Galenos Yayınevi.Aim: The aim of this study was to investigate whether urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum ischemia-modified albumin (IMA) levels could serve as early biomarkers of contrast-induced acute kidney injury (CI-AKI) in patients with normal serum creatinine values who undergo coronary angiography (CAG). Methods: This study was conducted in 78 patients undergoing CAG. Urinary NGAL and serum IMA values which measured prior to and 6 hours after CAG were compared with creatinine values that measured prior to and 48 hours after CAG. Results: IMA and NGAL values obtained 6 hours after CAG differed significantly from those obtained at baseline. Statistically significant differences were found between the baseline and 6th-hour values of urinary NGAL and serum IMA (p<0.001). There was no significant difference between baseline and 48th hour serum creatinine levels (p=0.081). In addition, a statistically significant positive correlation was found between pre-processing and 6th-hour NGAL and IMA levels, (r=0.277, p=0.014; r=0.407 and p<0.001, respectively). Conclusion: An increase in urinary NGAL and serum IMA levels were detected without an increase in serum creatinine values which is routinely used in determining CI-AKI. When compared.