Increased frequency of sister chromatid exchanges in peripheral lymphocytes of alcoholics and cigarette smokers


Karaoǧuz M. Y., COŞAR B., ARIKAN Z., Başaran F., Menevşe A., Menevşe S.

Cell Biology International, vol.29, no.2, pp.165-168, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1016/j.cellbi.2004.11.019
  • Journal Name: Cell Biology International
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.165-168
  • Keywords: sister chromatid exchange (SCE), lymphocyte culture, alcoholics, cigarette smokers, GENE-TOX PROGRAM, CHROMOSOMAL-ABERRATIONS, ETHANOL, CARCINOGENS, AGE
  • Lokman Hekim University Affiliated: No

Abstract

Sister chromatid exchange (SCE) is a sensitive indicator of genotoxicity. In this study we investigated the effects of alcohol consumption and cigarette smoking on the frequency of SCE in cultures of peripheral lymphocytes. The rate was higher in alcoholics who smoked (10.89±2.46) and in smokers (positive controls) (7.64±1.01) than in healthy non-smokers (negative controls) (6.96±2.18). Statistical analysis suggested that the increases were related to alcohol consumption and cigarette smoking (p<0.05). © 2004 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.