Naringenin and Atherosclerosis: A Review of Literature


ERDOĞAN ORHAN İ., Nabavi S. F., Daglia M., Tenore G. C., Mansouri K., Nabavi S. M.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY, cilt.16, sa.3, ss.245-251, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 16 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2174/1389201015666141202110216
  • Dergi Adı: CURRENT PHARMACEUTICAL BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.245-251
  • Anahtar Kelimeler: Atherosclerosis, flavonoid, grapefruit, naringenin, naringin, oxidative stress, LOW-DENSITY-LIPOPROTEIN, CORONARY-HEART-DISEASE, INDUCED OXIDATIVE STRESS, LDL-CHOLESTEROL LEVELS, DIET-INDUCED OBESITY, PPAR-GAMMA AGONISTS, KAPPA-B ACTIVATION, IN-VIVO, ANTIHEMOLYTIC ACTIVITIES, ENDOTHELIAL DYSFUNCTION
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Atherosclerosis is a multifactorial disease mainly caused by deposition of low-density lipoprotein (LD) cholesterol in macrophages of arterial walls. Atherosclerosis leads to heart attacks as well as stroke. Epidemiological studies showed that there is an inverse correlation between fruit and vegetable consumption and the risk of atherosclerosis. The promising effect of high vegetable and fruit containing diet on atherosclerosis is approved by several experimental studies on isolated phytochemicals such as flavonoids. Flavonoids are known to up-regulate endogenous antioxidant system, suppress oxidative and nitrosative stress, decrease macrophage oxidative stress through cellular oxygenase inhibition as well as interaction with several signal transduction pathways and from these ways, have therapeutic effects against atherosclerosis. Naringenin is a well known flavonoid belonging to the chemical class of flavanones. It is especially abundant in citrus fruits, especially grapefruits. A plethora of evidences ascribes to naringenin anti-atherosclerotic effects. Naringenin abilities to decrease LDL and triglycerides as well as inhibit glucose uptake; increase high-density lipoprotein (HDL); co-oxidation of NADH; suppress protein oxidation; protect against intercellular adhesion molecule-1(ICAM-1); suppress macrophage inflammation; inhibit leukotriene B4, monocyte adhesion and foam cell formation; induce of HO-1 and G 0/G 1 cell cycle arrest in vascular smooth muscle cells (VSMC) and down regulate atherosclerosis related genes are believed to have crucial role in the promising role against atherosclerosis. In the present review, we have summarized the available literature data on the anti-atherosclerotic effects of naringenin and its possible mechanisms of action.