The role of sucralfate in the treatment of nasal Synechia

Yildirim E., Ozcan K. M., ATAN D., Dere H.

Kuwait Medical Journal, vol.49, no.3, pp.212-215, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 3
  • Publication Date: 2017
  • Journal Name: Kuwait Medical Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.212-215
  • Keywords: nasal surgery, postoperative complications, sucralfate, synechia, topical, ENDOSCOPIC SINUS SURGERY, MITOMYCIN-C, MIDDLE MEATUS, STENOSIS, PREVENTION, ADHESIONS
  • Lokman Hekim University Affiliated: Yes


© 2017, Kuwait Medical Association. All rights reserved.Objective: Synechia is an important and frequently encountered complication of nasal surgery. Recurrent synechia can be seen after synechia correction surgeries. Sucralfate has recently come up with its topical use in healing epithelial wounds. Design: Retrospective analyses of prospective recorded data Setting: Department of Otorhinolaryngology, Numune Education and Research Hospital, Ankara, Turkey Subjects: Records of 16 patients who had previously undergone nasal surgery were investigated. Nasal synechia was detected in their controls and they underwent surgery for synechiae correction. During the synechiae correction surgery of 16 patients, topical sucralfate was used in 11 different synechiae regions in nine patients in group A and in the control group (Group B), it was not used in 9 separate regions in 7 patients. Interventions: Nine patients in group A received topical sucralfate. Seven patients in group B had surgery without topical sucralfate. Main outcome measure: We have investigated the effect of topical application of sucralfate on the success of nasal synechia correction surgery. Results: Recurrent synechia wasn’t detected in group A, treated with topical sucralfate, whereas in the control group, seven patients had recurrent synechia in three of the nine separate regions. When statistically analyzed, recurrence is seen to be much lower in group A. Conclusion: In conclusion, topical use of sucralfate in synechia correction surgery applied in cases of postoperative nasal synechiae increases the success rate of surgery.