Microbiological and clinical comparison of chlorhexidine buccoadhesive tablet and chlorhexidine mouthrinse

AKTAŞ A., GIRAY B., ÇAPAN Y., MENEMENLIOGLU D., HAYRAN M., IKINCI G., ...More

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol.19, no.5, pp.353-357, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 5
  • Publication Date: 2009
  • Doi Number: 10.1016/s1773-2247(09)50073-1
  • Journal Name: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.353-357
  • Keywords: Controlled release, Chlorhexidine, Buccoadhesive Tablet, IN-VIVO EVALUATION, FORMULATION, GLUCONATE, DELIVERY, DEVICE
  • Lokman Hekim University Affiliated: No

Abstract

Chlorhexidine, which is a gold standard for antiplaque agents, was prepared (is a buccoadhesive controlled-release drug formulation. The released amount and effectiveness of the antibacterial properties of the formulations were determined in in vivo and in vitro studies. In laboratory studies, nearly 40% of the total amount of the drug was released over 4 h. Clinically, first day results up to 4 h showed a statistically significant reduction of the bacterial amount in the drug-loaded side of oral mucosa. The results for 1 and 4 days were not statistically significant in the tablet group. The usefulness of the tablet dosage form was also assessed in the subjects.