Long-term voice results of injection with hyaluronic acid-dextranomere in unilateral vocal fold paralysis

OĞUZ H., Demirci M., Arslan N., Arslan E.

Acta Oto-Laryngologica, vol.133, no.5, pp.513-517, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 133 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.3109/00016489.2012.750034
  • Journal Name: Acta Oto-Laryngologica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.513-517
  • Keywords: Voice disorder, dysphonia, acoustic analysis, injection laryngoplasty, thyroidectomy, AUTOLOGOUS FAT INJECTION, CORD PARALYSIS, LARYNGOPLASTY, THYROPLASTY, COMPLICATIONS, OUTCOMES
  • Lokman Hekim University Affiliated: Yes


Conclusion: Subjective and objective voice evaluation of patients injected with hyaluronic acid-dextranomere (HA-D) in the long term was not different from their preoperative values. HA-D injection does not provide an increase in the voice quality in the long term. Objective: This study was conducted to evaluate the long-term voice outcomes of injection with HA-D in patients with unilateral vocal fold paralysis (UVFP). Methods: Seventeen patients with UVFP underwent injection of HA-D. The patient group was composed of 13 women and 4 men with an age range of 34-56 years. The voice samples of patients were obtained before the injection and after the longest available follow-up. Long-term results were evaluated subjectively by the GRBAS scale and objectively by acoustic analysis. Results: The follow-up period was between 6 and 42 months. Fundamental frequency, jitter, and noise-to-harmonics ratio were decreased in the postoperative period. Shimmer was nearly the same. An increase in the S score and a decrease in R, B, and A scores were observed. Neither the GRBAS scale parameters nor the acoustic analysis results were statistically significantly different before injection and after long-term follow-up. © 2013 Informa Healthcare.