Prediction of gestational diabetes mellitus in the first trimester by fasting plasma glucose which cutoff is better?

Ozgu-Erdinc A. S., Sert U. Y., ÇELİK H., Moraloglu Tekin O., Engin-Ustun Y.

Archives of Physiology and Biochemistry, vol.128, no.1, pp.195-199, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1080/13813455.2019.1671457
  • Journal Name: Archives of Physiology and Biochemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.195-199
  • Keywords: Gestational diabetes, screening, cutoff, first trimester, ONE-STEP, INSULIN-RESISTANCE, NORMAL-PREGNANCY, PRENATAL VISIT, DIAGNOSIS, HYPERGLYCEMIA, MANAGEMENT, CRITERIA, 2-STEP, CLASSIFICATION
  • Lokman Hekim University Affiliated: No

Abstract

© 2019 Informa UK Limited, trading as Taylor & Francis Group.Objective: We aimed to predict subsequent gestational diabetes mellitus (GDM) by fasting plasma glucose (FPG) in the first trimester. Methods: Healthy pregnant women who were screened for GDM at 24–28 gestational weeks and had FPG levels calculated during their first antenatal visit and less than 14 gestational weeks were included in this study. Results: Of the 2605 women who were recruited for the study, 245 (9.4%) were diagnosed with GDM at weeks 24–28. The diagnostic accuracy for FPG predicting GDM was 66.5, 78.4, and 88.2 for the cutoff values of 87.5 mg/dl, 92 mg/dl, and 99.5 mg/dl, respectively. Conclusions: FPG values which are within the normoglycaemic range constitute an independent risk factor for the development of GDM. The threshold for gestational diabetes diagnosis must be revised.