Humulane and germacrane sesquiterpenes from ferula lycia

Alkhatib R., Hennebelle T., Joha S., Roumy V., Güzel Y., Biabiany M., ...More

Journal of Natural Products, vol.73, no.4, pp.780-783, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.1021/np900827a
  • Journal Name: Journal of Natural Products
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.780-783
  • Lokman Hekim University Affiliated: No


Five new juniferol esters (1-5), along with six known humulane derivatives (6-11), were isolated from the roots of Ferula lycia, an endemic Turkish species. The fruits of the same species were also investigated and led to the isolation of these same compounds, as well as two known germacrane esters (12 and 13). All isolated sesquiterpenes were assayed for cytotoxicity against two tyrosine kinase inhibitor-resistant cell lines, K562R and DA1-3b/M2 BCR-ABL. The two most active compounds, juniferinin (7) and 6-β-p-hydroxybenzoyloxygermacra-1(10),4-diene (12), were moderately active against Raji lymphoma cells but also displayed some toxicity against healthy bone marrow cells. © 2010 The American Chemical Society and American Society of Pharmacognosy.