Elevated concentrations of soluble adhesion molecules and large platelets in diabetic patients: Are they markers of vascular disease and diabetic nephropathy?

Bavbek N., Kargili A., Kaftan O., Karakurt F., KOŞAR A. , Akcay A.

Clinical and Applied Thrombosis/Hemostasis, vol.13, no.4, pp.391-397, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1177/1076029607303615
  • Title of Journal : Clinical and Applied Thrombosis/Hemostasis
  • Page Numbers: pp.391-397
  • Keywords: diabetes mellitus, complications, mean platelet volume, P-selectin, E-selectin, CORONARY-HEART-DISEASE, MYOCARDIAL-INFARCTION, MELLITUS, VOLUME, RETINOPATHY, COMPLICATIONS, ACTIVATION, DIAGNOSIS, IDDM, PATHOGENESIS

Abstract

P-selectin, E-selectin, and mean platelet volume are markers associated with platelet reactivity that have been demonstrated to be increased in diabetes. We were particularly interested to see if there was a difference in mean platelet volume and selectins between diabetics and nondiabetics, and in diabetics with and without nephropathy, and whether there was a correlation between mean platelet volume and selectins. One hundred and fourteen diabetic patients and 31 healthy controls were investigated. Plasma levels of P-selectin and E-selectin were higher in the diabetic group than in controls (P =.001 and P =.007, respectively) and in diabetic patients with proteinuria than in patients without proteinuria (P =.002 and P =.004, respectively). Protein excretion was lower in patients with low mean platelet volume values (P =.004). In conclusion, elevated platelet volume and high selectin values may play a role in the development of vasculopathies and complications in diabetes mellitus. Further studies are needed to prove these results. © 2007 Sage Publications.